Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatment of cancer

Gelijkaardige items

• Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective Mammalian Target of Rapamycin (mTOR) inhibitor for the treatment of cancer
  door: Liu, Qingsong, et al.
  Gepubliceerd in: (2010)
• Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines
  door: Bernardino, Alice MR, et al.
  Gepubliceerd in: (2012)
• 1,3-Diphenyl-3,4-dihydro­benzo[b][1,6]naphthyridine
  door: Seebacher, Werner, et al.
  Gepubliceerd in: (2010)
• Anti-thrombotic activity of a benzo(c)(1,6)naphthyridine.
  door: Ott, H, et al.
  Gepubliceerd in: (1971)
• Efficient synthesis of 1,9-substituted benzo[h][1,6]naphthyridin-2(1H)-ones and evaluation of their Plasmodium falciparum gametocytocidal activities
  door: Li, Hao, et al.
  Gepubliceerd in: (2017)