Efficient synthesis of 1,9-substituted benzo[h][1,6]naphthyridin-2(1H)-ones and evaluation of their Plasmodium falciparum gametocytocidal activities

A novel three-component, two-step, one-pot nucleophilic aromatic substitution (S(N)Ar)–intramolecular cyclization-Suzuki coupling reaction was developed for the synthesis of benzo[h][1,6]naphthyridin-2(1H)-ones (Torins). Based on the new efficiently convergent synthetic route, a library of Torin ana...

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Pubblicato in:ACS Comb Sci
Autori principali: Li, Hao, Sun, Wei, Huang, Xiuli, Lu, Xiao, Patel, Paresma R., Kim, Myunghoon, Orr, Meghan J., Fisher, Richard M., Tanaka, Takeshi Q, McKew, John C., Simeonov, Anton, Sanderson, Philip E., Zheng, Wei, Williamson, Kim C., Huang, Wenwei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870878/
https://ncbi.nlm.nih.gov/pubmed/29024590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.7b00119
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