Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC

Por Tchaicha, Jeremy H., Akbay, Esra A., Altabef, Abigail, Mikse, Oliver R., Kikuchi, Eiki, Rhee, Kevin, Liao, Rachel G., Bronson, Roderick T., Sholl, Lynette M., Meyerson, Matthew, Hammerman, Peter S., Wong, Kwok-Kin
Publicado em 2014

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

Por Chipumuro, Edmond, Marco, Eugenio, Christensen, Camilla L., Kwiatkowski, Nicholas, Zhang, Tinghu, Hatheway, Clark M., Abraham, Brian J., Sharma, Bandana, Yeung, Caleb, Altabef, Abigail, Perez-Atayde, Antonio, Wong, Kwok-Kin, Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., George, Rani E.
Publicado no Cell (2014)

Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance

Por Chen, Zhao, Akbay, Esra, Mikse, Oliver, Tupper, Tanya, Cheng, Katherine, Wang, Yuchuan, Tan, Xiaohong, Altabef, Abigail, Woo, Sue-Ann, Chen, Liang, Reibel, Jacob B., Janne, Pasi A., Sharpless, Norman E., Engelman, Jeffrey A., Shapiro, Geoffrey I., Kung, Andrew L., Wong, Kwok-Kin
Publicado em 2013

Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM and ATR

Por Liu, Qingsong, Xu, Chunxiao, Kirubakaran, Sivapriya, Zhang, Xin, Hur, Wooyoung, Liu, Yan, Kwiatkowski, Nicholas P., Wang, Jinhua, Westover, Kenneth D., Gao, Peng, Ercan, Dalia, Niepel, Mario, Thoreen, Carson C., Kang, Seong A., Patricelli, Matthew P., Wang, Yuchuan, Tupper, Tanya, Altabef, Abigail, Kawamura, Hidemasa, Held, Kathryn D., Chou, Danny M., Elledge, Stephen J., Janne, Pasi A., Wong, Kwok-Kin, Sabatini, David M., Gray, Nathanael S.
Publicado em 2013

Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression

Por Xu, Chunxiao, Fillmore, Christine M., Koyama, Shohei, Wu, Hongbo, Zhao, Yanqiu, Chen, Zhao, Herter-Sprie, Grit S., Akbay, Esra A., Tchaicha, Jeremy H., Altabef, Abigail, Reibel, Jacob B., Walton, Zandra, Ji, Hongbin, Watanabe, Hideo, Jänne, Pasi A., Castrillon, Diego H., Rustgi, Anil K., Bass, Adam J., Freeman, Gordon J., Padera, Robert F., Dranoff, Glenn, Hammerman, Peter S., Kim, Carla F., Wong, Kwok-Kin
Publicado em 2014

Targeting Transcriptional Addictions In Small Cell Lung Cancer With a Covalent CDK7 Inhibitor

Por Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian, Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani, Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin
Publicado no Cancer Cell (2014)

Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors

Por Akbay, Esra A, Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H, Christensen, Camilla L, Mikse, Oliver R, Cherniack, Andrew D, Beauchamp, Ellen M, Pugh, Trevor J, Wilkerson, Matthew D, Fecci, Peter E, Butaney, Mohit, Reibel, Jacob B, Soucheray, Margaret, Cohoon, Travis J, Janne, Pasi A, Meyerson, Matthew, Hayes, D. Neil, Shapiro, Geoffrey I, Shimamura, Takeshi, Sholl, Lynette M, Rodig, Scott J, Freeman, Gordon J, Hammerman, Peter S, Dranoff, Glenn, Wong, Kwok-Kin
Publicado em 2013

STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T cell activity in the lung tumor microenvironment

Por Koyama, Shohei, Akbay, Esra A., Li, Yvonne Y., Aref, Amir R., Skoulidis, Ferdinandos, Herter-Sprie, Grit S., Buczkowski, Kevin A., Liu, Yan, Awad, Mark M., Denning, Warren L., Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R., Wistuba, Ignacio I., Soucheray, Margaret, Thai, Tran C., Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D., Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E., Shimamura, Takeshi, Hellmann, Matthew D., Heymach, John V., Hodi, F. Stephen, Freeman, Gordon J., Barbie, David A., Dranoff, Glenn, Hammerman, Peter S., Wong, Kwok-Kin
Publicado no Cancer Res (2016)

A murine lung cancer co–clinical trial identifies genetic modifiers of therapeutic response

Por Chen, Zhao, Cheng, Katherine, Walton, Zandra, Wang, Yuchuan, Ebi, Hiromichi, Shimamura, Takeshi, Liu, Yan, Tupper, Tanya, Ouyang, Jing, Li, Jie, Gao, Peng, Woo, Michele S., Xu, Chunxiao, Yanagita, Masahiko, Altabef, Abigail, Wang, Shumei, Lee, Charles, Nakada, Yuji, Peña, Christopher G., Sun, Yanping, Franchetti, Yoko, Yao, Catherine, Saur, Amy, Cameron, Michael D., Nishino, Mizuki, Hayes, D. Neil, Wilkerson, Matthew D., Roberts, Patrick J., Lee, Carrie B., Bardeesy, Nabeel, Butaney, Mohit, Chirieac, Lucian R., Costa, Daniel B., Jackman, David, Sharpless, Norman E., Castrillon, Diego H., Demetri, George D., Jänne, Pasi A., Pandolfi, Pier Paolo, Cantley, Lewis C., Kung, Andrew L., Engelman, Jeffrey A., Wong, Kwok-Kin
Publicado em 2012

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a target in LKB1 Mutant Lung Cancer

Por Liu, Yan, Marks, Kevin, Cowley, Glenn S., Carretero, Julian, Liu, Qingsong, Nieland, Thomas J.F., Xu, Chunxiao, Cohoon, Travis J., Gao, Peng, Zhang, Yong, Chen, Zhao, Altabef, Abigail B., Tchaicha, Jeremy H., Wang, Xiaoxu, Choe, Sung, Driggers, Edward M., Zhang, Jianming, Bailey, Sean T., Sharpless, Norman E., Hayes, D. Neil, Patel, Nirali M., Janne, Pasi A., Bardeesy, Nabeel, Engelman, Jeffrey A., Manning, Brendan D., Shaw, Reuben J., Asara, John M., Scully, Ralph, Kimmelman, Alec, Byers, Lauren A., Gibbons, Don L., Wistuba, Ignacio I, Heymach, John V., Kwiatkowski, David J., Kim, William Y., Kung, Andrew L., Gray, Nathanael S., Root, David E., Cantley, Lewis C., Wong, Kwok-Kin
Publicado em 2013