Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment

Por Herter-Sprie, Grit S., Greulich, Heidi, Wong, Kwok-Kin
Publicado em 2013

New cast for a new era: preclinical cancer drug development revisited

Por Herter-Sprie, Grit S., Kung, Andrew L., Wong, Kwok-Kin
Publicado em 2013

Posttranscriptional regulation of gene expression—adding another layer of complexity to the DNA damage response

Por Boucas, Jorge, Riabinska, Arina, Jokic, Mladen, Herter-Sprie, Grit S., Chen, Shuhua, Höpker, Katja, Reinhardt, H. Christian
Publicado em 2012

AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation

Por Herter, Jan M., Grabie, Nir, Cullere, Xavier, Azcutia, Veronica, Rosetti, Florencia, Bennett, Paul, Herter-Sprie, Grit S., Elyaman, Wassim, Luscinskas, Francis W., Lichtman, Andrew H., Mayadas, Tanya N.
Publicado no Nat Commun (2015)

Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models

Por Herter-Sprie, Grit S., Korideck, Houari, Christensen, Camilla L., Herter, Jan M., Rhee, Kevin, Berbeco, Ross I., Bennett, David G., Akbay, Esra A., Kozono, David, Mak, Raymond H., Makrigiorgos, G. Mike, Kimmelman, Alec C., Wong, Kwok-Kin
Publicado no Nat Commun (2014)

Development of Selective Covalent Janus Kinase 3 Inhibitors

Por Tan, Li, Akahane, Koshi, McNally, Randall, Reyskens, Kathleen M. S. E., Ficarro, Scott B., Liu, Suhu, Herter-Sprie, Grit S., Koyama, Shohei, Pattison, Michael J., Labella, Katherine, Johannessen, Liv, Akbay, Esra A., Wong, Kwok-Kin, Frank, David A., Marto, Jarrod A., Look, Thomas A., Arthur, J. Simon C., Eck, Michael J., Gray, Nathanael S.
Publicado no J Med Chem (2015)

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

Por Herter-Sprie, Grit S., Koyama, Shohei, Korideck, Houari, Hai, Josephine, Deng, Jiehui, Li, Yvonne Y., Buczkowski, Kevin A., Grant, Aaron K., Ullas, Soumya, Rhee, Kevin, Cavanaugh, Jillian D., Neupane, Neermala Poudel, Christensen, Camilla L., Herter, Jan M., Makrigiorgos, G. Mike, Hodi, F. Stephen, Freeman, Gordon J., Dranoff, Glenn, Hammerman, Peter S., Kimmelman, Alec C., Wong, Kwok-Kin
Publicado no JCI Insight (2016)

Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression

Por Xu, Chunxiao, Fillmore, Christine M., Koyama, Shohei, Wu, Hongbo, Zhao, Yanqiu, Chen, Zhao, Herter-Sprie, Grit S., Akbay, Esra A., Tchaicha, Jeremy H., Altabef, Abigail, Reibel, Jacob B., Walton, Zandra, Ji, Hongbin, Watanabe, Hideo, Jänne, Pasi A., Castrillon, Diego H., Rustgi, Anil K., Bass, Adam J., Freeman, Gordon J., Padera, Robert F., Dranoff, Glenn, Hammerman, Peter S., Kim, Carla F., Wong, Kwok-Kin
Publicado em 2014

Targeting Transcriptional Addictions In Small Cell Lung Cancer With a Covalent CDK7 Inhibitor

Por Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian, Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani, Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin
Publicado no Cancer Cell (2014)

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

Por Koyama, Shohei, Akbay, Esra A., Li, Yvonne Y., Herter-Sprie, Grit S., Buczkowski, Kevin A., Richards, William G., Gandhi, Leena, Redig, Amanda J., Rodig, Scott J., Asahina, Hajime, Jones, Robert E., Kulkarni, Meghana M., Kuraguchi, Mari, Palakurthi, Sangeetha, Fecci, Peter E., Johnson, Bruce E., Janne, Pasi A., Engelman, Jeffrey A., Gangadharan, Sidharta P., Costa, Daniel B., Freeman, Gordon J., Bueno, Raphael, Hodi, F. Stephen, Dranoff, Glenn, Wong, Kwok-Kin, Hammerman, Peter S.
Publicado no Nat Commun (2016)

Multiparametric profiling of non–small-cell lung cancers reveals distinct immunophenotypes

Por Lizotte, Patrick H., Ivanova, Elena V., Awad, Mark M., Jones, Robert E., Keogh, Lauren, Liu, Hongye, Dries, Ruben, Almonte, Christina, Herter-Sprie, Grit S., Santos, Abigail, Feeney, Nora B., Paweletz, Cloud P., Kulkarni, Meghana M., Bass, Adam J., Rustgi, Anil K., Yuan, Guo-Cheng, Kufe, Donald W., Jänne, Pasi A., Hammerman, Peter S., Sholl, Lynette M., Hodi, F. Stephen, Richards, William G., Bueno, Raphael, English, Jessie M., Bittinger, Mark A., Wong, Kwok-Kin
Publicado no JCI Insight (2016)

Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer

Por Zhang, Haikuo, Qi, Jun, Reyes, Jaime M., Li, Lewyn, Rao, Prakash K., Li, Fugen, Lin, Charles Y., Perry, Jennifer A., Lawlor, Matthew A., Federation, Alexander, De Raedt, Thomas, Li, Yvonne Y., Liu, Yan, Duarte, Melissa A., Zhang, Yanxi, Herter-Sprie, Grit S., Kikuchi, Eiki, Carretero, Julian, Perou, Charles M., Reibel, Jacob B., Paulk, Joshiawa, Bronson, Roderick T., Watanabe, Hideo, Fillmore, Christine M., Kim, Carla F., Hammerman, Peter S., Brown, Myles, Cichowski, Karen, Long, Henry, Bradner, James E., Wong, Kwok-Kin
Publicado no Cancer Discov (2016)

STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T cell activity in the lung tumor microenvironment

Por Koyama, Shohei, Akbay, Esra A., Li, Yvonne Y., Aref, Amir R., Skoulidis, Ferdinandos, Herter-Sprie, Grit S., Buczkowski, Kevin A., Liu, Yan, Awad, Mark M., Denning, Warren L., Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R., Wistuba, Ignacio I., Soucheray, Margaret, Thai, Tran C., Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D., Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E., Shimamura, Takeshi, Hellmann, Matthew D., Heymach, John V., Hodi, F. Stephen, Freeman, Gordon J., Barbie, David A., Dranoff, Glenn, Hammerman, Peter S., Wong, Kwok-Kin
Publicado no Cancer Res (2016)

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

Por Zhang, Haikuo, Fillmore Brainson, Christine, Koyama, Shohei, Redig, Amanda J., Chen, Ting, Li, Shuai, Gupta, Manav, Garcia-de-Alba, Carolina, Paschini, Margherita, Herter-Sprie, Grit S., Lu, Gang, Zhang, Xin, Marsh, Bryan P., Tuminello, Stephanie J., Xu, Chunxiao, Chen, Zhao, Wang, Xiaoen, Akbay, Esra A., Zheng, Mei, Palakurthi, Sangeetha, Sholl, Lynette M., Rustgi, Anil K., Kwiatkowski, David J., Diehl, J Alan, Bass, Adam J., Sharpless, Norman E., Dranoff, Glenn, Hammerman, Peter S., Ji, Hongbin, Bardeesy, Nabeel, Saur, Dieter, Watanabe, Hideo, Kim, Carla F., Wong, Kwok-Kin
Publicado no Nat Commun (2017)