Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

Radiation therapy (RT), a critical modality in the treatment of lung cancer, induces direct tumor cell death and augments tumor-specific immunity. However, despite initial tumor control, most patients suffer from locoregional relapse and/or metastatic disease following RT. The use of immunotherapy i...

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Publicado en:JCI Insight
Autores principales: Herter-Sprie, Grit S., Koyama, Shohei, Korideck, Houari, Hai, Josephine, Deng, Jiehui, Li, Yvonne Y., Buczkowski, Kevin A., Grant, Aaron K., Ullas, Soumya, Rhee, Kevin, Cavanaugh, Jillian D., Neupane, Neermala Poudel, Christensen, Camilla L., Herter, Jan M., Makrigiorgos, G. Mike, Hodi, F. Stephen, Freeman, Gordon J., Dranoff, Glenn, Hammerman, Peter S., Kimmelman, Alec C., Wong, Kwok-Kin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033933/
https://ncbi.nlm.nih.gov/pubmed/27699275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87415
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