Palbociclib resistance confers dependence on an FGFR-MAP kinase-mTOR-driven pathway in KRAS-mutant non-small cell lung cancer

CDK4 is emerging as a target in KRAS-mutant non-small cell lung cancer (NSCLC). We demonstrate that KRAS-mutant NSCLC cell lines are initially sensitive to the CDK4/6 inhibitor palbociclib, but readily acquire resistance associated with increased expression of CDK6, D-type cyclins and cyclin E. Resi...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Haines, Eric, Chen, Ting, Kommajosyula, Naveen, Chen, Zhao, Herter-Sprie, Grit S., Cornell, Liam, Wong, Kwok-Kin, Shapiro, Geoffrey I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Priority Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6114982/
https://ncbi.nlm.nih.gov/pubmed/30167080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25803
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