Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

Radiation therapy (RT), a critical modality in the treatment of lung cancer, induces direct tumor cell death and augments tumor-specific immunity. However, despite initial tumor control, most patients suffer from locoregional relapse and/or metastatic disease following RT. The use of immunotherapy i...

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Enregistré dans:
Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Herter-Sprie, Grit S., Koyama, Shohei, Korideck, Houari, Hai, Josephine, Deng, Jiehui, Li, Yvonne Y., Buczkowski, Kevin A., Grant, Aaron K., Ullas, Soumya, Rhee, Kevin, Cavanaugh, Jillian D., Neupane, Neermala Poudel, Christensen, Camilla L., Herter, Jan M., Makrigiorgos, G. Mike, Hodi, F. Stephen, Freeman, Gordon J., Dranoff, Glenn, Hammerman, Peter S., Kimmelman, Alec C., Wong, Kwok-Kin
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033933/
https://ncbi.nlm.nih.gov/pubmed/27699275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87415
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