Autophagy sustains pancreatic cancer growth through both cell autonomous and non-autonomous mechanisms

Autophagy has been shown to be elevated in pancreatic adenocarcinoma (PDAC) and its role in promoting established tumor growth has made it a promising therapeutic target. However, due to limitations of prior mouse models as well as the lack of potent and selective autophagy inhibitors, the ability t...

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Publicado en:Cancer Discov
Autores principales: Yang, Annan, Herter-Sprie, Grit, Zhang, Haikuo, Lin, Elaine Y., Biancur, Douglas, Wang, Xiaoxu, Deng, Jiehui, Hai, Josephine, Yang, Shenghong, Wong, Kwok-Kin, Kimmelman, Alec C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835190/
https://ncbi.nlm.nih.gov/pubmed/29317452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0952
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