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Inhibition of autophagy attenuates pancreatic cancer growth independent of TP53/TRP53 status
Basal levels of autophagy are elevated in most pancreatic ductal adenocarcinomas (PDAC). Suppressing autophagy pharmacologically using chloroquine (CQ) or genetically with RNAi to essential autophagy genes inhibits human pancreatic cancer growth in vitro and in vivo, which presents possible treatmen...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4206544/ https://ncbi.nlm.nih.gov/pubmed/25046107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.29961 |
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