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Inhibition of autophagy attenuates pancreatic cancer growth independent of TP53/TRP53 status

Basal levels of autophagy are elevated in most pancreatic ductal adenocarcinomas (PDAC). Suppressing autophagy pharmacologically using chloroquine (CQ) or genetically with RNAi to essential autophagy genes inhibits human pancreatic cancer growth in vitro and in vivo, which presents possible treatmen...

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Bibliografiske detaljer
Main Authors: Yang, Annan, Kimmelman, Alec C
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206544/
https://ncbi.nlm.nih.gov/pubmed/25046107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.29961
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