Taming of the beast: Shaping Myc-dependent amplification

Por Wolf, Elmar, Lin, Charles Y., Eilers, Martin, Levens, David L.
Publicado no Trends Cell Biol (2014)

Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes

Por Semenkovich, Nicholas P., Planer, Joseph D., Ahern, Philip P., Griffin, Nicholas W., Lin, Charles Y., Gordon, Jeffrey I.
Publicado no Proc Natl Acad Sci U S A (2016)

SR Proteins Collaborate with 7SK and Promoter-Associated Nascent RNA to Release Paused Polymerase

Por Ji, Xiong, Zhou, Yu, Pandit, Shatakshi, Huang, Jie, Li, Hairi, Lin, Charles Y., Xiao, Rui, Burge, Christopher B., Fu, Xiang-Dong
Publicado em 2013

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers

Por Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y., Weintraub, Abraham S., Abraham, Brian J., Lee, Tong Ihn, Bradner, James E., Young, Richard A.
Publicado no Mol Cell (2015)

Global control of cell cycle transcription by coupled CDK and network oscillators

Por Orlando, David A., Lin, Charles Y., Bernard, Allister, Wang, Jean Y., Socolar, Joshua E. S., Iversen, Edwin S., Hartemink, Alexander J., Haase, Steven B.
Publicado em 2008

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Por Lin, Charles Y., Lovén, Jakob, Rahl, Peter B., Paranal, Ronald M., Burge, Christopher B., Bradner, James E., Lee, Tong Ihn, Young, Richard A.
Publicado em 2012

Models of human core transcriptional regulatory circuitries

Por Saint-André, Violaine, Federation, Alexander J., Lin, Charles Y., Abraham, Brian J., Reddy, Jessica, Lee, Tong Ihn, Bradner, James E., Young, Richard A.
Publicado no Genome Res (2016)

c-Myc regulates transcriptional pause release

Por Rahl, Peter B., Lin, Charles Y., Seila, Amy C., Flynn, Ryan A., McCuine, Scott, Burge, Christopher B., Sharp, Phillip A., Young, Richard A.
Publicado em 2010

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Por Lovén, Jakob, Hoke, Heather A., Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.
Publicado em 2013

Revisiting Global Gene Expression Analysis

Por Lovén, Jakob, Orlando, David A., Sigova, Alla A., Lin, Charles Y., Rahl, Peter B., Burge, Christopher B., Levens, David L., Lee, Tong Ihn, Young, Richard A.
Publicado em 2012

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Por Whyte, Warren A., Orlando, David A., Hnisz, Denes, Abraham, Brian J., Lin, Charles Y., Kagey, Michael H., Rahl, Peter B., Lee, Tong Ihn, Young, Richard A.
Publicado em 2013

Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

Por Nabet, Behnam, Broin, Pilib Ó, Reyes, Jaime M., Shieh, Kevin, Lin, Charles Y., Will, Christine M., Popovic, Relja, Ezponda, Teresa, Bradner, James E., Golden, Aaron A., Licht, Jonathan D.
Publicado no Cell Rep (2015)

PI3K/AKT signaling regulates H3K4 methylation in breast cancer

Por Spangle, Jennifer M, Dreijerink, Koen M, Groner, Anna C, Cheng, Hailing, Ohlson, Carolynn E, Reyes, Jaime, Lin, Charles Y, Bradner, James, Zhao, Jean J, Roberts, Thomas M, Brown, Myles
Publicado no Cell Rep (2016)

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers is Suppressed by a MicroRNA

Por Stratton, Matthew S., Lin, Charles Y., Anand, Priti, Tatman, Philip D., Ferguson, Bradley S., Wickers, Sean T., Ambardekar, Amrut V., Sucharov, Carmen C., Bradner, James E., Haldar, Saptarsi M., McKinsey, Timothy A.
Publicado no Cell Rep (2016)

NF-kB directs dynamic super enhancer formation in inflammation and atherogenesis

Por Brown, Jonathan D., Lin, Charles Y., Duan, Qiong, Griffin, Gabriel, Federation, Alexander, Paranal, Ronald M., Bair, Steven, Newton, Gail, Lichtman, Andrew, Kung, Andrew, Yang, Tianlun, Wang, Hong, Luscinskas, Francis W., Croce, Kevin, Bradner, James E., Plutzky, Jorge
Publicado no Mol Cell (2014)

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

Por Anand, Priti, Brown, Jonathan D., Lin, Charles Y., Qi, Jun, Zhang, Rongli, Artero, Pedro Calderon, Alaiti, M. Amer, Bullard, Jace, Alazem, Kareem, Margulies, Kenneth B., Cappola, Thomas P., Lemieux, Madeleine, Plutzky, Jorge, Bradner, James E., Haldar, Saptarsi M.
Publicado em 2013

Discovery and Characterization of Super-Enhancer Associated Dependencies in Diffuse Large B-Cell Lymphoma

Por Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G, Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.
Publicado em 2013

Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer

Por Heyn, Holger, Vidal, Enrique, Ferreira, Humberto J., Vizoso, Miguel, Sayols, Sergi, Gomez, Antonio, Moran, Sebastian, Boque-Sastre, Raquel, Guil, Sonia, Martinez-Cardus, Anna, Lin, Charles Y., Royo, Romina, Sanchez-Mut, Jose V., Martinez, Ramon, Gut, Marta, Torrents, David, Orozco, Modesto, Gut, Ivo, Young, Richard A., Esteller, Manel
Publicado no Genome Biol (2016)

DHODH modulates transcriptional elongation in the neural crest and melanoma

Por White, Richard Mark, Cech, Jennifer, Ratanasirintrawoot, Sutheera, Lin, Charles Y., Rahl, Peter B., Burke, Christopher J., Langdon, Erin, Tomlinson, Matthew L., Mosher, Jack, Kaufman, Charles, Chen, Frank, Long, Hannah K., Kramer, Martin, Datta, Sumon, Neuberg, Donna, Granter, Scott, Young, Richard A., Morrison, Sean, Wheeler, Grant N., Zon, Leonard I.
Publicado em 2011

Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer

Por Zhang, Haikuo, Qi, Jun, Reyes, Jaime M., Li, Lewyn, Rao, Prakash K., Li, Fugen, Lin, Charles Y., Perry, Jennifer A., Lawlor, Matthew A., Federation, Alexander, De Raedt, Thomas, Li, Yvonne Y., Liu, Yan, Duarte, Melissa A., Zhang, Yanxi, Herter-Sprie, Grit S., Kikuchi, Eiki, Carretero, Julian, Perou, Charles M., Reibel, Jacob B., Paulk, Joshiawa, Bronson, Roderick T., Watanabe, Hideo, Fillmore, Christine M., Kim, Carla F., Hammerman, Peter S., Brown, Myles, Cichowski, Karen, Long, Henry, Bradner, James E., Wong, Kwok-Kin
Publicado no Cancer Discov (2016)