Unexpected pieces to the senescence puzzle

per Cichowski, Karen, Hahn, William C.
Publicat 2008

Identifying the ubiquitin ligase complex that regulates the NF1 tumor suppressor and Ras

per Hollstein, Pablo E., Cichowski, Karen
Publicat 2013

SPRED proteins provide a NF-ty link to Ras suppression

per McClatchey, Andrea I., Cichowski, Karen
Publicat 2012

Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is

per Liao, Sida, Maertens, Ophélia, Cichowski, Karen, Elledge, Stephen J.
Publicat a Genes Dev (2018)

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

per Cichowski, Karen, Santiago, Sabrina, Jardim, Melanie, Johnson, Bryan W., Jacks, Tyler
Publicat 2003

The NF1 tumor suppressor critically regulates TSC2 and mTOR

per Johannessen, Cory M., Reczek, Elizabeth E., James, Marianne F., Brems, Hilde, Legius, Eric, Cichowski, Karen
Publicat 2005

Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers

per Malone, Clare F., Fromm, Jody A., Maertens, Ophélia, DeRaedt, Thomas, Ingraham, Rachel, Cichowski, Karen
Publicat a Cancer Discov (2014)

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

per Johnson, Leisa, Greenbaum, Doron, Cichowski, Karen, Mercer, Kim, Murphy, Elizabeth, Schmitt, Eric, Bronson, Roderick T., Umanoff, Heywood, Edelmann, Windfried, Kucherlapati, Raju, Jacks, Tyler
Publicat 1997

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

per Engelman, Jeffrey A., Jänne, Pasi A., Mermel, Craig, Pearlberg, Joseph, Mukohara, Toru, Fleet, Christina, Cichowski, Karen, Johnson, Bruce E., Cantley, Lewis C.
Publicat 2005

Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers

per Lock, Rebecca, Ingraham, Rachel, Maertens, Ophélia, Miller, Abigail L., Weledji, Nelly, Legius, Eric, Konicek, Bruce M., Yan, Sau-Chi B., Graff, Jeremy R., Cichowski, Karen
Publicat a J Clin Invest (2016)

A negative feedback signaling network underlies oncogene-induced senescence

per Courtois-Cox, Stéphanie, Genther Williams, Sybil M., Reczek, Elizabeth E., Johnson, Bryan W., McGillicuddy, Lauren T., Johannessen, Cory M., Hollstein, Pablo, MacCollin, Mia, Cichowski, Karen
Publicat 2006

The RasGAP Gene, RASAL2, is a Tumor and Metastasis Suppressor

per McLaughlin, Sara Koenig, Olsen, Sarah Naomi, Dake, Benjamin, De Raedt, Thomas, Lim, Elgene, Bronson, Roderick Terry, Beroukhim, Rameen, Polyak, Kornelia, Brown, Myles, Kuperwasser, Charlotte, Cichowski, Karen
Publicat 2013

mTOR and HDAC inhibitors converge on the TXNIP/thioredoxin pathway to cause catastrophic oxidative stress and regression of RAS-driven tumors

per Malone, Clare F., Emerson, Chloe, Ingraham, Rachel, Barbosa, William, Guerra, Stephanie, Yoon, Haejin, Liu, Lin L., Michor, Franziska, Haigis, Marcia, Macleod, Kay F., Maertens, Ophélia, Cichowski, Karen
Publicat a Cancer Discov (2017)

Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity

per Zhang, Yang, Guillermier, Christelle, De Raedt, Thomas, Cox, Andrew G., Maertens, Ophelia, Yimlamai, Dean, Lun, Mingyue, Whitney, Adam, Maas, Richard L., Goessling, Wolfram, Cichowski, Karen, Steinhauser, Matthew L.
Publicat a iScience (2020)

Elucidating distinct roles for NF1 in melanomagenesis

per Maertens, Ophélia, Johnson, Bryan, Hollstein, Pablo, Frederick, Dennie T., Cooper, Zachary A., Messiaen, Ludwine, Bronson, Roderick T., McMahon, Martin, Granter, Scott, Flaherty, Keith, Wargo, Jennifer A., Marais, Richard, Cichowski, Karen
Publicat 2012

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

per Takahashi, Nobuaki, Chen, Hsing-Yu, Harris, Isaac S., Stover, Daniel G., Selfors, Laura M., Bronson, Roderick T., Deraedt, Thomas, Cichowski, Karen, Welm, Alana L., Mori, Yasuo, Mills, Gordon B., Brugge, Joan S.
Publicat a Cancer Cell (2018)

IL1α antagonizes IL1β and promotes adaptive immune rejection of malignant tumors

per Tian, Tian, Lofftus, Serena, Pan, Youdong, Stingley, Claire A, King, Sandra L, Zhao, Jingxia, Pan, Timothy Y, Lock, Rebecca, Marglous, Jacob W, Liu, Kevin, Widlund, Hans R, Fuhlbrigge, Robert, Cichowski, Karen, Kupper, Thomas S
Publicat a Cancer Immunol Res (2020)

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy

per Montero, Joan, Sarosiek, Kristopher A., DeAngelo, Joseph D., Maertens, Ophélia, Ryan, Jeremy, Ercan, Dalia, Piao, Huiying, Horowitz, Neil S., Berkowitz, Ross S., Matulonis, Ursula, Jänne, Pasi A., Amrein, Philip C., Cichowski, Karen, Drapkin, Ronny, Letai, Anthony
Publicat a Cell (2015)

A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies

per Maertens, Ophélia, McCurrach, Mila E., Braun, Benjamin S., De Raedt, Thomas, Epstein, Inbal, Huang, Tannie Q., Lauchle, Jennifer O., Lee, Hyerim, Wu, Jianqiang, Cripe, Timothy P., Clapp, D. Wade, Ratner, Nancy, Shannon, Kevin, Cichowski, Karen
Publicat a Cancer Res (2017)

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and NF-κB

per Min, Junxia, Zaslavsky, Alexander, Fedele, Giuseppe, McLaughlin, Sara K., Reczek, Elizabeth E., De Raedt, Thomas, Guney, Isil, Strochlic, David E., Laura, E., Beroukhim, Rameen, Bronson, Roderick T., Ryeom, Sandra, Hahn, William C., Loda, Massimo, Cichowski, Karen
Publicat 2010