K-ras is an essential gene in the mouse with partial functional overlap with N-ras

Mammalian ras genes are thought to be critical in the regulation of cellular proliferation and differentiation and are mutated in ∼30% of all human tumors. However, N-ras and H-ras are nonessential for mouse development. To characterize the normal role of K-ras in growth and development, we have mut...

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Main Authors: Johnson, Leisa, Greenbaum, Doron, Cichowski, Karen, Mercer, Kim, Murphy, Elizabeth, Schmitt, Eric, Bronson, Roderick T., Umanoff, Heywood, Edelmann, Windfried, Kucherlapati, Raju, Jacks, Tyler
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1997
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC316567/
https://ncbi.nlm.nih.gov/pubmed/9334313
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