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Genetic Interaction between Rb and K-ras in the Control of Differentiation and Tumor Suppression

Although the retinoblastoma protein (pRb) has been implicated in the processes of cellular differentiation, there is no compelling genetic or in vivo evidence that such activities contribute to pRb-mediated tumor suppression. Motivated by cell culture studies suggesting that Ras is a downstream effe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Takahashi, Chiaki, Contreras, Bernardo, Bronson, Roderick T., Loda, Massimo, Ewen, Mark E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC529028/
https://ncbi.nlm.nih.gov/pubmed/15542848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.23.10406-10415.2004
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