ARF mutation accelerates pituitary tumor development in Rb+/− mice

Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop pituitary and thyroid tumors with high penetrance. We demonstrate here that loss of the ARF tumor suppressor strongly accelerates intermediate lobe pituitary tumorigenesis in Rb heterozygous mice. These effects in the pituit...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Tsai, Kenneth Y., MacPherson, David, Rubinson, Douglas A., Nikitin, Alexander Yu., Bronson, Roderick, Mercer, Kim L., Crowley, Denise, Jacks, Tyler
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12486224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.262499599
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