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ARF mutation accelerates pituitary tumor development in Rb+/− mice
Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop pituitary and thyroid tumors with high penetrance. We demonstrate here that loss of the ARF tumor suppressor strongly accelerates intermediate lobe pituitary tumorigenesis in Rb heterozygous mice. These effects in the pituit...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139235/ https://ncbi.nlm.nih.gov/pubmed/12486224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262499599 |
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