ARF mutation accelerates pituitary tumor development in Rb+/− mice

Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop pituitary and thyroid tumors with high penetrance. We demonstrate here that loss of the ARF tumor suppressor strongly accelerates intermediate lobe pituitary tumorigenesis in Rb heterozygous mice. These effects in the pituit...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Tsai, Kenneth Y., MacPherson, David, Rubinson, Douglas A., Nikitin, Alexander Yu., Bronson, Roderick, Mercer, Kim L., Crowley, Denise, Jacks, Tyler
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2002
Teme:	Biological Sciences
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12486224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.262499599
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