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ARF mutation accelerates pituitary tumor development in Rb+/− mice

Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop pituitary and thyroid tumors with high penetrance. We demonstrate here that loss of the ARF tumor suppressor strongly accelerates intermediate lobe pituitary tumorigenesis in Rb heterozygous mice. These effects in the pituit...

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Main Authors: Tsai, Kenneth Y., MacPherson, David, Rubinson, Douglas A., Nikitin, Alexander Yu., Bronson, Roderick, Mercer, Kim L., Crowley, Denise, Jacks, Tyler
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC139235/
https://ncbi.nlm.nih.gov/pubmed/12486224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262499599
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