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ARF mutation accelerates pituitary tumor development in Rb+/− mice

Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop pituitary and thyroid tumors with high penetrance. We demonstrate here that loss of the ARF tumor suppressor strongly accelerates intermediate lobe pituitary tumorigenesis in Rb heterozygous mice. These effects in the pituit...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Tsai, Kenneth Y., MacPherson, David, Rubinson, Douglas A., Nikitin, Alexander Yu., Bronson, Roderick, Mercer, Kim L., Crowley, Denise, Jacks, Tyler
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139235/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12486224/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.262499599
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