ARF mutation accelerates pituitary tumor development in Rb+/− mice

Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop pituitary and thyroid tumors with high penetrance. We demonstrate here that loss of the ARF tumor suppressor strongly accelerates intermediate lobe pituitary tumorigenesis in Rb heterozygous mice. These effects in the pituit...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Tsai, Kenneth Y., MacPherson, David, Rubinson, Douglas A., Nikitin, Alexander Yu., Bronson, Roderick, Mercer, Kim L., Crowley, Denise, Jacks, Tyler
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2002
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12486224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.262499599
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