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ARF mutation accelerates pituitary tumor development in Rb+/− mice
Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop pituitary and thyroid tumors with high penetrance. We demonstrate here that loss of the ARF tumor suppressor strongly accelerates intermediate lobe pituitary tumorigenesis in Rb heterozygous mice. These effects in the pituit...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139235/ https://ncbi.nlm.nih.gov/pubmed/12486224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262499599 |
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