Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1

door Karlseder, Jan, Kachatrian, Leili, Takai, Hiroyuki, Mercer, Kim, Hingorani, Sunil, Jacks, Tyler, de Lange, Titia
Gepubliceerd in 2003

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

door McClatchey, Andrea I., Saotome, Ichiko, Mercer, Kim, Crowley, Denise, Gusella, James F., Bronson, Roderick T., Jacks, Tyler
Gepubliceerd in 1998

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

door Jackson, Erica L., Willis, Nicholas, Mercer, Kim, Bronson, Roderick T., Crowley, Denise, Montoya, Raymond, Jacks, Tyler, Tuveson, David A.
Gepubliceerd in 2001

ARF mutation accelerates pituitary tumor development in Rb+/− mice

door Tsai, Kenneth Y., MacPherson, David, Rubinson, Douglas A., Nikitin, Alexander Yu., Bronson, Roderick, Mercer, Kim L., Crowley, Denise, Jacks, Tyler
Gepubliceerd in 2002

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

door Johnson, Leisa, Greenbaum, Doron, Cichowski, Karen, Mercer, Kim, Murphy, Elizabeth, Schmitt, Eric, Bronson, Roderick T., Umanoff, Heywood, Edelmann, Windfried, Kucherlapati, Raju, Jacks, Tyler
Gepubliceerd in 1997

CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer

door Ng, Sheng Rong, Rideout, William M., Akama-Garren, Elliot H., Bhutkar, Arjun, Mercer, Kim L., Schenkel, Jason M., Bronson, Roderick T., Jacks, Tyler
Gepubliceerd in Proc Natl Acad Sci U S A (2020)

Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells

door Melnikova, Margarita, Wauer, Ulrike Sophie, Mendus, Diana, Hilger, Ralf Axel, Oliver, Trudy G., Mercer, Kim, Gohlke, Björn Oliver, Erdmann, Kati, Niederacher, Dieter, Neubauer, Hans, Buderath, Paul, Wimberger, Pauline, Kuhlmann, Jan Dominik, Thomale, Jürgen
Gepubliceerd in Mol Oncol (2020)

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

door Kirsch, David G., Santiago, Philip M., di Tomasso, Emmanuelle, Sullivan, Julie M., Hou, Wu-Shiun, Dayton, Talya, Jeffords, Laura B., Sodha, Pooja, Mercer, Kim, Cohen, Rhianna, Takeuchi, Osamu, Korsmeyer, Stanley J., Bronson, Roderick, Kim, Carla F., Haigis, Kevin M., Jain, Rakesh K., Jacks, Tyler
Gepubliceerd in 2009

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

door Oliver, Trudy G., Mercer, Kim L., Sayles, Leanne C., Burke, James R., Mendus, Diana, Lovejoy, Katherine S., Cheng, Mei-Hsin, Subramanian, Aravind, Mu, David, Powers, Scott, Crowley, Denise, Bronson, Roderick T., Whittaker, Charles A., Bhutkar, Arjun, Lippard, Stephen J., Golub, Todd, Thomale, Juergen, Jacks, Tyler, Sweet-Cordero, E. Alejandro
Gepubliceerd in 2010

Identification of DHODH as a therapeutic target in small cell lung cancer

door Li, Leanne, Ng, Sheng Rong, Colón, Caterina I., Drapkin, Benjamin J., Hsu, Peggy P., Li, Zhaoqi, Nabel, Christopher S., Lewis, Caroline A., Romero, Rodrigo, Mercer, Kim L., Bhutkar, Arjun, Phat, Sarah, Myers, David T., Muzumdar, Mandar Deepak, Westcott, Peter M. K., Beytagh, Mary Clare, Farago, Anna F., Vander Heiden, Matthew G., Dyson, Nicholas J., Jacks, Tyler
Gepubliceerd in Sci Transl Med (2019)