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SPRED proteins provide a NF-ty link to Ras suppression
Mutations in the SPRED1 (Sprouty-related protein with an EVH [Ena/Vasp homology] domain 1) and NF1 (neurofibromatosis 1) genes underlie clinically related human disorders. The NF1-encoded protein neurofibromin is a Ras GTPase-activating protein (GAP) and can directly limit Ras activity. Spred protei...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2012
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404379/ https://ncbi.nlm.nih.gov/pubmed/22802525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.197434.112 |
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