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The NF1 tumor suppressor critically regulates TSC2 and mTOR
Loss-of-function mutations in the NF1 tumor suppressor gene underlie the familial cancer syndrome neurofibromatosis type I (NF1). The NF1-encoded protein, neurofibromin, functions as a Ras-GTPase activating protein (RasGAP). Accordingly, deregulation of Ras is thought to contribute to NF1 developmen...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1142482/ https://ncbi.nlm.nih.gov/pubmed/15937108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503224102 |
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