The NF1 tumor suppressor critically regulates TSC2 and mTOR

Loss-of-function mutations in the NF1 tumor suppressor gene underlie the familial cancer syndrome neurofibromatosis type I (NF1). The NF1-encoded protein, neurofibromin, functions as a Ras-GTPase activating protein (RasGAP). Accordingly, deregulation of Ras is thought to contribute to NF1 developmen...

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Bibliografiset tiedot
Päätekijät: Johannessen, Cory M., Reczek, Elizabeth E., James, Marianne F., Brems, Hilde, Legius, Eric, Cichowski, Karen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2005
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142482/
https://ncbi.nlm.nih.gov/pubmed/15937108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503224102
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