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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. Here, we investigate how inhibition of the widely expressed transcriptional coactivator BRD4 leads to selective in...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3760967/ https://ncbi.nlm.nih.gov/pubmed/23582323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.03.036 |
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