Activation of proto-oncogenes by disruption of chromosome neighborhoods

Oncogenes are activated through well-known chromosomal alterations, including gene fusion, translocation and focal amplification. Recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods led us to investigate whether proto-oncogenes occur within t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Science
Egile Nagusiak: Hnisz, Denes, Weintraub, Abraham S., Day, Daniel S., Valton, Anne-Laure, Bak, Rasmus O., Li, Charles H., Goldmann, Johanna, Lajoie, Bryan R., Fan, Zi Peng, Sigova, Alla A., Reddy, Jessica, Borges-Rivera, Diego, Lee, Tong Ihn, Jaenisch, Rudolf, Porteus, Matthew H., Dekker, Job, Young, Richard A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884612/
https://ncbi.nlm.nih.gov/pubmed/26940867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad9024
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