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Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers

Super-enhancers and stretch enhancers (SEs) drive expression of genes that play prominent roles in normal and disease cells, but the functional importance of these clustered enhancer elements is poorly understood, so it is not clear why genes key to cell identity have evolved regulation by such elem...

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Dettagli Bibliografici
Pubblicato in:Mol Cell
Autori principali: Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y., Weintraub, Abraham S., Abraham, Brian J., Lee, Tong Ihn, Bradner, James E., Young, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402134/
https://ncbi.nlm.nih.gov/pubmed/25801169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.02.014
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