Activation of proto-oncogenes by disruption of chromosome neighborhoods

Oncogenes are activated through well-known chromosomal alterations, including gene fusion, translocation and focal amplification. Recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods led us to investigate whether proto-oncogenes occur within t...

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Pubblicato in:Science
Autori principali: Hnisz, Denes, Weintraub, Abraham S., Day, Daniel S., Valton, Anne-Laure, Bak, Rasmus O., Li, Charles H., Goldmann, Johanna, Lajoie, Bryan R., Fan, Zi Peng, Sigova, Alla A., Reddy, Jessica, Borges-Rivera, Diego, Lee, Tong Ihn, Jaenisch, Rudolf, Porteus, Matthew H., Dekker, Job, Young, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884612/
https://ncbi.nlm.nih.gov/pubmed/26940867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad9024
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