Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers is Suppressed by a MicroRNA

BRD4 governs pathological cardiac gene expression by binding acetylated chromatin, resulting in enhanced RNA polymerase II (Pol II) phosphorylation and transcription elongation. Here, we describe a signal-dependent mechanism for regulation of BRD4 in cardiomyocytes. BRD4 expression is suppressed by...

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Publicado en:Cell Rep
Main Authors: Stratton, Matthew S., Lin, Charles Y., Anand, Priti, Tatman, Philip D., Ferguson, Bradley S., Wickers, Sean T., Ambardekar, Amrut V., Sucharov, Carmen C., Bradner, James E., Haldar, Saptarsi M., McKinsey, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972677/
https://ncbi.nlm.nih.gov/pubmed/27425608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.074
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