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Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRas(G12V) or loss of negative feedback through Sprouty gene deletion r...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551578/ https://ncbi.nlm.nih.gov/pubmed/26279576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.078 |
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