Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRas(G12V) or loss of negative feedback through Sprouty gene deletion r...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Nabet, Behnam, Broin, Pilib Ó, Reyes, Jaime M., Shieh, Kevin, Lin, Charles Y., Will, Christine M., Popovic, Relja, Ezponda, Teresa, Bradner, James E., Golden, Aaron A., Licht, Jonathan D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551578/
https://ncbi.nlm.nih.gov/pubmed/26279576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.078
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