PI3K/AKT signaling regulates H3K4 methylation in breast cancer

Posttranslational histone H3 modifications regulate transcriptional competence. The mechanisms by which the epigenome is regulated in response to oncogenic signaling remain unclear. Here we show increased H3K4me3 in vivo in breast tumors driven by an activated PIK3CA allele and inhibition of PI3K/AK...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Spangle, Jennifer M, Dreijerink, Koen M, Groner, Anna C, Cheng, Hailing, Ohlson, Carolynn E, Reyes, Jaime, Lin, Charles Y, Bradner, James, Zhao, Jean J, Roberts, Thomas M, Brown, Myles
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094353/
https://ncbi.nlm.nih.gov/pubmed/27292631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.046
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