PI3K/AKT signaling regulates H3K4 methylation in breast cancer

Posttranslational histone H3 modifications regulate transcriptional competence. The mechanisms by which the epigenome is regulated in response to oncogenic signaling remain unclear. Here we show increased H3K4me3 in vivo in breast tumors driven by an activated PIK3CA allele and inhibition of PI3K/AK...

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Vydáno v:Cell Rep
Hlavní autoři: Spangle, Jennifer M, Dreijerink, Koen M, Groner, Anna C, Cheng, Hailing, Ohlson, Carolynn E, Reyes, Jaime, Lin, Charles Y, Bradner, James, Zhao, Jean J, Roberts, Thomas M, Brown, Myles
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094353/
https://ncbi.nlm.nih.gov/pubmed/27292631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.046
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