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PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α
Mutation or loss of the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3K) is emerging as a transforming factor in cancer, but the mechanism of transformation has been controversial. Here we find that hemizygous deletion of the PIK3R1 gene encoding p85α is a frequent event in breast canc...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5502636/ https://ncbi.nlm.nih.gov/pubmed/28630349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704706114 |
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