PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α

Mutation or loss of the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3K) is emerging as a transforming factor in cancer, but the mechanism of transformation has been controversial. Here we find that hemizygous deletion of the PIK3R1 gene encoding p85α is a frequent event in breast canc...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Thorpe, Lauren M., Spangle, Jennifer M., Ohlson, Carolynn E., Cheng, Hailing, Roberts, Thomas M., Cantley, Lewis C., Zhao, Jean J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502636/
https://ncbi.nlm.nih.gov/pubmed/28630349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704706114
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