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BRD7, a tumor suppressor, interacts with p85alpha and regulates PI3K activity
Phosphoinositide 3-kinase (PI3K) activity is important for regulating cell growth, survival and motility. We report here the identification of bromodomain-containing protein 7 (BRD7) as a p85α-interacting protein that negatively regulates PI3K signaling. BRD7 binds to the inter-SH2 (iSH2) domain of...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4004185/ https://ncbi.nlm.nih.gov/pubmed/24657164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.02.016 |
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