The PI3K regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signalling

PI3K plays a critical role in tumorigenesis and the PI3K p85 regulatory subunit exerts both positive and negative effects on signaling. Expression of Pik3r1, the gene encoding p85, is decreased in human prostate, lung, ovarian, bladder and liver cancers consistent with the possibility that p85 has t...

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Bibliografiske detaljer
Main Authors: Taniguchi, Cullen M., Winnay, Jonathon, Kondo, Tatsuya, Bronson, Roderick T., Guimaraes, Alexander R., Aleman, José O., Luo, Ji, Stephanopoulos, Gregory, Weissleder, Ralph, Cantley, Lewis C., Kahn, C. Ronald
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204358/
https://ncbi.nlm.nih.gov/pubmed/20530665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3399
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