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Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN

The phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin on liver. Here, we show that mice with a liver-specific deletion of the p85α regulatory subunit of PI3K (L-Pik3r1KO) exhibit a paradoxical improvement of hepatic and peripheral insulin sensitivity. Although P...

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Main Authors: Taniguchi, Cullen M., Tran, Thien T., Kondo, Tatsuya, Luo, Ji, Ueki, Kohjiro, Cantley, Lewis C., Kahn, C. Ronald
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1524929/
https://ncbi.nlm.nih.gov/pubmed/16880400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604628103
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