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Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN
The phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin on liver. Here, we show that mice with a liver-specific deletion of the p85α regulatory subunit of PI3K (L-Pik3r1KO) exhibit a paradoxical improvement of hepatic and peripheral insulin sensitivity. Although P...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1524929/ https://ncbi.nlm.nih.gov/pubmed/16880400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604628103 |
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