Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α()

The p85α regulatory subunit of class I(A) phosphoinositide 3-kinases (PI3K) is derived from the Pik3r1 gene, which also yields alternatively spliced variants p50α and p55α. It has been proposed that excess monomeric p85 competes with functional PI3K p85-p110 heterodimers. We examined embryonic stem...

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Detalhes bibliográficos
Main Authors: Hallmann, Daniel, Trümper, Katja, Trusheim, Heidi, Ueki, Kohjiro, Kahn, C. Ronald, Cantley, Lewis C., Fruman, David A., Hörsch, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205087/
https://ncbi.nlm.nih.gov/pubmed/12435753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M208451200
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