Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival

Class Ia phosphoinositide (PI) 3-kinase is a central component in growth factor signaling and is comprised of a p110 catalytic subunit and a regulatory subunit, the most common family of which is derived from the p85α gene (Pik3r1). Optimal signaling through the PI 3-kinase pathway depends on a crit...

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Detalhes bibliográficos
Main Authors: Ueki, Kohjiro, Fruman, David A., Brachmann, Saskia M., Tseng, Yu-Hua, Cantley, Lewis C., Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133541/
https://ncbi.nlm.nih.gov/pubmed/11784871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.3.965-977.2002
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