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A Novel Interaction Between the Regulatory Subunit of PI 3-Kinase and X-box Binding Protein-1 Modulates the Unfolded Protein Response
Class Ia phosphoinositide (PI) 3-kinase, an essential mediator of the metabolic actions of insulin, is composed of a catalytic (p110α) and regulatory (p85α) subunit. Here we demonstrate that p85α interacts with X-box binding protein-1 (XBP-1), a transcriptional mediator of the unfolded protein respo...
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| Publicado no: | Nat Med |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371606/ https://ncbi.nlm.nih.gov/pubmed/20348923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2121 |
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