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A Novel Interaction Between the Regulatory Subunit of PI 3-Kinase and X-box Binding Protein-1 Modulates the Unfolded Protein Response

Class Ia phosphoinositide (PI) 3-kinase, an essential mediator of the metabolic actions of insulin, is composed of a catalytic (p110α) and regulatory (p85α) subunit. Here we demonstrate that p85α interacts with X-box binding protein-1 (XBP-1), a transcriptional mediator of the unfolded protein respo...

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Vydáno v:Nat Med
Hlavní autoři: Winnay, Jonathon N., Boucher, Jeremie, Mori, Marcelo, Ueki, Kohjiro, Kahn, C. Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371606/
https://ncbi.nlm.nih.gov/pubmed/20348923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2121
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