BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K

Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family that is known to play role as tumor suppressors. Here, we show that BRD7 is a component of the unfolded protein response (UPR) signaling through its ability to regulate X-box binding protein1 (XBP1) nucl...

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Autors principals: Park, Sang Won, Herrema, Hilde, Salazar, Mario, Cakir, Isin, Cabi, Serkan, Sahin, Fatma Basibuyuk, Chiu, Yu-Hsin, Cantley, Lewis C., Ozcan, Umut
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079724/
https://ncbi.nlm.nih.gov/pubmed/24836559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.04.006
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