P38 MAPK REGULATED XBP1s NUCLEAR TRANSLOCATION AND mRNA STABILITY ARE CRUCIAL FOR MAINTENANCE OF GLUCOSE HOMEOSTASIS IN OBESITY

Here we show that p38 mitogen activated protein kinase (p38 MAPK) phosphorylates spliced form of X-Box Binding Protein 1 (XBP1s) on Thr48 and Ser61 residues and greatly enhances nuclear migration of XBP1s. Mutation of Thr48 and Ser61 to alanine dramatically reduces nuclear translocation of XBP1s and...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Sun, Cheng, Lee, Jaemin, Zhou, Yingjiang, Lee, Justin, Gokalp, Deniz, Herrema, Hilde, Park, Sang Won, Davis, Roger J., Ozcan, Umut
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397266/
https://ncbi.nlm.nih.gov/pubmed/21892182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2449
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