P38 MAPK REGULATED XBP1s NUCLEAR TRANSLOCATION AND mRNA STABILITY ARE CRUCIAL FOR MAINTENANCE OF GLUCOSE HOMEOSTASIS IN OBESITY

Here we show that p38 mitogen activated protein kinase (p38 MAPK) phosphorylates spliced form of X-Box Binding Protein 1 (XBP1s) on Thr48 and Ser61 residues and greatly enhances nuclear migration of XBP1s. Mutation of Thr48 and Ser61 to alanine dramatically reduces nuclear translocation of XBP1s and...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Sun, Cheng, Lee, Jaemin, Zhou, Yingjiang, Lee, Justin, Gokalp, Deniz, Herrema, Hilde, Park, Sang Won, Davis, Roger J., Ozcan, Umut
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397266/
https://ncbi.nlm.nih.gov/pubmed/21892182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2449
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