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PI3Kα oncogenic mutations weaken the interactions that stabilize the p110α/p85α heterodimer
Phosphatidylinositol 3-kinase α (PI3Kα) is a heterodimeric lipid kinase that catalyzes the conversion of phosphoinositide-4,5-bisphosphate (PIP(2)) to phosphoinositide-3,4,5-trisphosphate (PIP(3)). The PI3Kα signaling pathway plays an important role in cell growth, proliferation and survival. This p...
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| Publicado no: | FEBS J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4573839/ https://ncbi.nlm.nih.gov/pubmed/26122737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13365 |
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