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Insights into the oncogenic effects of PIK3CA mutations from the structure of p100α/p85α
Phosphatidylinositide-3-kinases (PI3K) initiate a number of signaling pathways by recruiting other kinases, such as Akt, to the plasma membrane. One of the isoforms, PI3Kα , is an oncogene frequently mutated in several cancer types. These mutations increase PI3K kinase activity, leading to increased...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3260475/ https://ncbi.nlm.nih.gov/pubmed/18418043 |
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