A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

Mutations in oncogenes often promote tumorigenesis by changing the conformation of the encoded proteins, thereby altering enzymatic activity. The PIK3CA oncogene, which encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα), is one of the two most frequently mutated onco...

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Main Authors: Mandelker, Diana, Gabelli, Sandra B., Schmidt-Kittler, Oleg, Zhu, Jiuxiang, Cheong, Ian, Huang, Chuan-Hsiang, Kinzler, Kenneth W., Vogelstein, Bert, Amzel, L. Mario
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2009
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761334/
https://ncbi.nlm.nih.gov/pubmed/19805105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908444106
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