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A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane
Mutations in oncogenes often promote tumorigenesis by changing the conformation of the encoded proteins, thereby altering enzymatic activity. The PIK3CA oncogene, which encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα), is one of the two most frequently mutated onco...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2761334/ https://ncbi.nlm.nih.gov/pubmed/19805105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908444106 |
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