A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

Mutations in oncogenes often promote tumorigenesis by changing the conformation of the encoded proteins, thereby altering enzymatic activity. The PIK3CA oncogene, which encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα), is one of the two most frequently mutated onco...

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Hlavní autoři: Mandelker, Diana, Gabelli, Sandra B., Schmidt-Kittler, Oleg, Zhu, Jiuxiang, Cheong, Ian, Huang, Chuan-Hsiang, Kinzler, Kenneth W., Vogelstein, Bert, Amzel, L. Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761334/
https://ncbi.nlm.nih.gov/pubmed/19805105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908444106
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