A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

Mutations in oncogenes often promote tumorigenesis by changing the conformation of the encoded proteins, thereby altering enzymatic activity. The PIK3CA oncogene, which encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα), is one of the two most frequently mutated onco...

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Bibliografiske detaljer
Main Authors: Mandelker, Diana, Gabelli, Sandra B., Schmidt-Kittler, Oleg, Zhu, Jiuxiang, Cheong, Ian, Huang, Chuan-Hsiang, Kinzler, Kenneth W., Vogelstein, Bert, Amzel, L. Mario
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761334/
https://ncbi.nlm.nih.gov/pubmed/19805105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908444106
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