A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

Mutations in oncogenes often promote tumorigenesis by changing the conformation of the encoded proteins, thereby altering enzymatic activity. The PIK3CA oncogene, which encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα), is one of the two most frequently mutated onco...

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書誌詳細
主要な著者: Mandelker, Diana, Gabelli, Sandra B., Schmidt-Kittler, Oleg, Zhu, Jiuxiang, Cheong, Ian, Huang, Chuan-Hsiang, Kinzler, Kenneth W., Vogelstein, Bert, Amzel, L. Mario
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2009
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761334/
https://ncbi.nlm.nih.gov/pubmed/19805105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908444106
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