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Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects
PI3Kα, a heterodimeric lipid kinase, catalyzes the conversion of phosphoinositide-4,5-bisphosphate (PIP(2)) to phosphoinositide-3,4,5-trisphosphate (PIP(3)), a lipid that recruits to the plasma membrane proteins that regulate signaling cascades that control key cellular processes such as cell prolif...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4192660/ https://ncbi.nlm.nih.gov/pubmed/25309634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12551-013-0131-1 |
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