Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects

PI3Kα, a heterodimeric lipid kinase, catalyzes the conversion of phosphoinositide-4,5-bisphosphate (PIP(2)) to phosphoinositide-3,4,5-trisphosphate (PIP(3)), a lipid that recruits to the plasma membrane proteins that regulate signaling cascades that control key cellular processes such as cell prolif...

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Hlavní autoři: Gabelli, Sandra B., Echeverria, Ignacia, Alexander, Megan, Duong-Ly, Krisna C., Chaves-Moreira, Daniele, Brower, Evan T., Vogelstein, B., Amzel, L. Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2014
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192660/
https://ncbi.nlm.nih.gov/pubmed/25309634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12551-013-0131-1
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