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Capitalizing on Tumor genotyping: Towards the design of mutation specific inhibitors of Phosphoinsitide-3-Kinase
Phosphatidylinositide-3-kinases (PI3K) PI3Kα, is a lipid kinase frequently mutated in several cancer types. Under normal physiological conditions it initiates a number of signaling pathways by recruiting other kinases, such as Akt, to the plasma membrane. The mutations observed in tumors increase PI...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079044/ https://ncbi.nlm.nih.gov/pubmed/21035489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.advenzreg.2010.09.013 |
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