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Kinase inhibitor profiling reveals unexpected opportunities to inhibit disease-associated mutant kinases
Small-molecule kinase inhibitors have typically been designed to inhibit wild-type kinases rather than the mutant forms that frequently arise in diseases such as cancer. Mutations can have serious clinical implications by increasing kinase catalytic activity or conferring therapeutic resistance. To...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4740242/ https://ncbi.nlm.nih.gov/pubmed/26776524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.080 |
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