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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
Small-molecule protein kinase inhibitors are central tools for elucidating cellular signaling pathways and are promising therapeutic agents. Due to evolutionary conservation of the ATP-binding site, most kinase inhibitors that target this site promiscuously inhibit multiple kinases. Interpretation o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230241/ https://ncbi.nlm.nih.gov/pubmed/22037377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2017 |
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