An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

Autoregulatory domains found within kinases may provide more unique targets for chemical inhibitors than the conserved ATP-binding pocket targeted by most inhibitors. The kinase Pak1 contains an autoinhibitory domain that suppresses the catalytic activity of its kinase domain. Pak1 activators reliev...

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Udgivet i:Chem Biol
Main Authors: Deacon, Sean W., Beeser, Alexander, Fukui, Jami A., Rennefahrt, Ulrike E. E., Myers, Cynthia, Chernoff, Jonathan, Peterson, Jeffrey R.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353635/
https://ncbi.nlm.nih.gov/pubmed/18420139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.03.005
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