A Highly Selective Dual Insulin Receptor (IR)/Insulin-like Growth Factor 1 Receptor (IGF-1R) Inhibitor Derived from an Extracellular Signal-regulated Kinase (ERK) Inhibitor

Dual inhibitors of the closely related receptor tyrosine kinases insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) are promising therapeutic agents in cancer. Here, we report an unusually selective class of dual inhibitors of IGF-1R and IR identified in a parallel screen of kn...

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Hauptverfasser: Anastassiadis, Theonie, Duong-Ly, Krisna C., Deacon, Sean W., Lafontant, Alec, Ma, Haiching, Devarajan, Karthik, Dunbrack, Roland L., Wu, Jinhua, Peterson, Jeffrey R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784719/
https://ncbi.nlm.nih.gov/pubmed/23935097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.505032
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