Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors

[Image: see text] Structural coverage of the human kinome has been steadily increasing over time. The structures provide valuable insights into the molecular basis of kinase function and also provide a foundation for understanding the mechanisms of kinase inhibitors. There are a large number of kina...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Vijayan, R. S. K., He, Peng, Modi, Vivek, Duong-Ly, Krisna C., Ma, Haiching, Peterson, Jeffrey R., Dunbrack, Roland L., Levy, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326797/
https://ncbi.nlm.nih.gov/pubmed/25478866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501603h
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